The map of the hippocampal-amygdalar circuitry and its implication in temporal emotion regulation
PonenteJingyi Wang. UCSB
Fecha21 de enero de 2022. 12:30 h.
LugarFacultad Medicina UAM. Madrid
CicloMáster Neurociencia IC-UAM
The amygdala projects to hippocampus in pathways through which affective or social stimuli may influence learning and memory. We investigated the still unknown amygdalar termination patterns and their postsynaptic targets in hippocampus from system to synapse in rhesus monkeys of both sexes. The amygdala robustly innervated the stratum lacunosum-moleculare layer of cornu ammonis fields and uncus anteriorly. Sparser terminations in posterior hippocampus innervated the radiatum and pyramidal layers at the prosubicular/CA1 juncture. The terminations, which were larger than other afferents in the surrounding neuropil, position the amygdala to influence hippocampal input anteriorly, and its output posteriorly. Most amygdalar boutons (76-80%) innervated spines of excitatory hippocampal neurons, and most of the remaining innervated presumed inhibitory neurons, identified by morphology and label with parvalbumin or calretinin, which distinguished nonoverlapping neurochemical classes of hippocampal inhibitory neurons.
Jingyi received her Ph.D. in 2020 under the mentorship of Helen Barbas at Boston University. Her graduate work in neuroanatomy identified novel pathways connecting the hippocampus, amygdala and anterior cingulate cortex in rhesus monkeys, and delineated the contributions of this network for emotional memory, motivation, and the representation of internal states. In the LEAP Neuro lab, Jingyi is investigating how the frontal pole interacts with cingulate cortex and amygdala during emotion regulation, as well as the impact of amygdala function on hippocampal temporal coding. The emotion is constantly interacting with our time perception and cognition, and failure of emotion regulation not only impact a healthy individual’s performance and can lead to psychiatric diseases. Jingyi’s research under the mentorship of Dr. Regina Lapate can help with understanding of our emotion in a system level and improve treatment for the psychiatric diseases.