Aberrant upregulation of the glycolytic enzyme PFKFB3 in CLN7 neuronal ceroid lipofuscinosis.
Lopez-Fabuel I, Garcia-Macia M, Buondelmonte C, Burmistrova O, Bonora N, Alonso-Batan P, Morant-Ferrando B, Vicente-Gutierrez C, Jimenez-Blasco D, Quintana-Cabrera R, Fernández E, Llop J, Ramos-Cabrer P, Sharaireh A, Guevara-Ferrer M, Fitzpatrick L, Thompton C, McKay T, Storch S, Medina D, Mole S, Fedichev P, Almeida A, and Bolaños JP.
NATURE COMUNICATIONS Jan 27;13(1):536 (2021)
DOI: 10.1038/s41467-022-28191-1
Opa1 relies on cristae preservation and ATP synthase to curtail reactive oxygen species accumulation in mitochondria
T2. Quintana-Cabrera R*, Manjarrés-Raza I, Vicente-Gutiérrez C, Corrado M, Bolaños JP, Scorrano, L* (*Autor de co correspondencia).
REDOX BIOLOGY March 19;41:101944 (2021)
DOI: 10.1016/j.redox.2021.101944
Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy
Zaninello M. Dr. Konstantinos Palikaras , Dr. Deborah Naon , Dr. Keiko Iwata , Dr. Stéphanie Herkenne , Dr. Ruben Quintana-Cabrera , Dr. Martina Semenzato , Dr. Francesca Grespi , Mr. Fred Ross-Cisneros , Dr. Valerio Carelli , Prof. Alfredo Sadun , Prof. Nektarios Tavernarakis, Luca Scorrano
NATURE COMUNICATIONS Aug 12; 11(1):4029 (2020)
DOI: 10.1038/s41467-020-17821-1
Intertwined ROS and Metabolic Signaling at the Neuron-Astrocyte Interface
Vicente-Gutiérrez C, Jiménez-Blasco D, Quintana-Cabrera R.
NEUROCHEMICAL RESEARCH Jan 27 (2020)
DOI: 10.1007/s11064-020-02965-9
ER stress priming of mitochondrial respiratory suPERKomplex assembly
Quintana-Cabrera, R., Soriano, M.E
TRENDS IN ENDOCRINOLOGY & METABOLISM Aug 24 (2019)
DOI: doi: 10.1016/j.tem.2019.08.003.
Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction.
6. Costa R, Peruzzo R, Bachmann M, Montà GD, Vicario M, Santinon G, Mattarei A, Moro E, Quintana-Cabrera R, Scorrano L, Zeviani M, Vallese F, Zoratti M, Paradisi C, Argenton F, Brini M, Calì T, Dupont S, Szabò I, Leanza L.
CELL REPORTS Aug 20;28(8):1949-1960.e6. (2019)
DOI: 10.1016/j.celrep.2019.07.050
PARP inhibitor PJ34 protects mitochondria and induces DNA-damage mediated apoptosis in combination with cisplatin or temozolomide in B16F10 melanoma cells.
Cseh A, Fábián Z, Quintana-Cabrera R ,Szabó A, Erős K, Soriano ME, Gallyas F, Scorrano L, Sümegi B.
FRONTIERS IN PHYSIOLOGY May 7;10:538 eCollection (2019)
DOI: 10.3389/fphys.2019.00538
MFN2 mutations in Charcot-Marie-Tooth disease alter mitochondria-associated ER membrane function but do not impair bioenergetics.
8. Larrea D, Pera M, Gonelli A, Quintana-Cabrera R, Akman HO, Guardia-Laguarta C, Velasco KR, Area-Gomez E, Dal Bello F, De Stefani D, Horvath R, Shy ME, Schon EA, Giacomello M.
HUMAN MOLECULAR GENETICS Jan 11 (2019)
DOI: 10.1093/hmg/ddz008
The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function.
Quintana-Cabrera, R, Quirin C, Glytsou C, Corrado M, Urbani A, Pellattiero A, Calvo E, Vázquez J, Enríquez JA, Gerle C, Soriano ME, Bernardi P, Scorrano L.
NATURE COMMUNICATIONS Aug 24 (2018)
DOI: 10.1038/s41467-018-05655-x
Who and how in the regulation of mitochondrial cristae shape and function.
Quintana-Cabrera R, Mehrotra A, Rigoni G, Soriano ME
BIOCHEM BIOPHYS RES COMMUN Apr 21. pii: S0006-291X(17)30763-5 (2017)
DOI: 0.1016/j.bbrc.2017.04.088
(Neuro)degenerated Mitochondria-ER contacts.
De Mario A, Quintana-Cabrera R, Martinvalet D, Giacomello M.
BIOCHEM BIOPHYS RES COMMUN Feb 19; 483(4):1096-1109. Special Issue: Neurodegeneration. Volume 483, Issue 4, Pages 979-1194 (19 February 2017) (2017)
DOI: 10.1503/jpn.150209
Early effects of the anti-neoplastic agent salinomycin on mitochondrial function.
12. Managò A., Leanza L., Carraretto L., Sassi N., Grancara S., Quintana-Cabrera R., Trimarco V., Toninello A., Scorrano L., Trentin L., Gulbins E., Zoratti M., Szabò I.
CELL DEATH DIS Oct 22; 6:e1930 (2015)
DOI: 10.1038/cddis.2015.263
Controlled overexpression of the mitochondria shaping protein Optic Atrophy 1 counteracts cellular damage in vivo.
Varanita T., Soriano M.E., Romanello V., Zaglia T., Quintana-Cabrera R., Semenzato M., Menabò R., Costa V., Civiletto G., Pesce P., Viscomi C., Zeviani M., Di Lisa F., Mongillo M., Sandri M., Scorrano L.
CELL METABOLISM Jun 2;21(6):834-442T2T (2015)
Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency.
ogliati S.; Frezza C.; Soriano ME.; Varanita T.; Quintana-Cabrera R.; Corrado M.; Cipolat S., Costa V., Casarin A., Gomes LC., Perales-Clemente E.; Salviati L.; Fernandez-Silva P.; Enriquez JA.; Scorrano L.
CELL Sep 26;155(1):160-71. (2013)
DOI: 10.1016/j.cell.2013.08.032
Glutathione and γ-glutamylcysteine in hydrogen peroxide detoxification.
Quintana-Cabrera R., Bolaños JP.
METHODS IN ENZYMOLOGY 527:129-44. Special Issue: Hydrogen Peroxide and cell signaling, Part B. Volume 527, Pages 2-321 (2013). Edited by Enrique Cadenas and Lester Packer (2013)
DOI: 10.1016/B978-0-12-405882-8.00007-6.
Glutathione and γ-glutamylcysteine in the antioxidant and survival functions of mitochondria.
Quintana-Cabrera R., Bolaños JP
BIOCHEM. SOC. TRANS.; Feb 1;41(1):106-10 (2013)
DOI: 10.1042/BST20120252
siRNA knock down of glutamate dehydrogenase in astrocytes affects glutamate metabolism leading to extensive accumulation of the neuroactive amino acids glutamate and aspartate.
Skytt DM; Klawonn AM; Stridh MH; Pajecka K; Patruss Y; Quintana-Cabrera, R.; Bolaños JP; Schousboe A.; Waagepetersen HS.
NEUROCHEMISTRY INTERNATIONAL Sep;61(4):490-7 (2012)
DOI: 10.1016/j.neuint.2012.04.014
γ-Glutamylcysteine detoxifies reactive oxygen species by acting as glutathione peroxidase-1 cofactor
Quintana-Cabrera, R.; Fernandez-Fernandez, S.; Bobo-Jimenez, V.; Escobar, J.; Sastre, J; Almeida, A.; Bolaños, J.P.
NATURE COMMUNICATIONS Mar 6;3:718 (2012)
DOI: DOI: 10.1038/ncomms1722