The use of Silica Microparticles to Improve the Efficiency of Optical Hyperthermia (OH)
Casanova-Carvajal, O; Zeinoun, M; Urbano-Bojorge, AL; Bacha, F; Livi, JS; Agudo, E; Vargas, G; Ramos, M; Martinez-Murillo, R; Serrano-Olmedo, JJ
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 22 (10) (2021)
DOI: 10.3390/ijms22105091

Reflections on cerebellar neuropathology in classical scrapie
Toledano-Díaz A, Álvarez MI, Rodríguez JJ, Badiola JJ, Monzón M, Toledano A.
BIOMOLECULES Apr 28; 11(5):649 (2021)
DOI: 10.3390/biom11050649

Synthesis, antioxidant properties and neuroprotection of alpha-phenyl-tert-butylnitrone derived HomoBisNitrones in in vitro and in vivo ischemia models
Chamorro, B; Diez-Iriepa, D; Merás-Sáiz, B; Chioua, M; García-Vieira, D; Iriepa, I; Hadjipavlou-Litina, D; López-Muñoz, F; Martínez-Murillo, R; Gonzàlez-Nieto, D; Israel Fernández, I; Marco-Contelles, J; and Oset-Gasque, MJesús
SCIENTIFIC REPORTS 10 (1), 2020
DOI: 10.1038/s41598-020-70690-y

Biomaterials to Neuroprotect the Stroke Brain: A Large Opportunity for Narrow Time Windows
Gonzalez-Nieto, D; Fernandez-Serra, R; Perez-Rigueiro, J; Panetsos, F Martinez-Murillo, R; Guinea, GV
CELLS 9 (5) (2020)
DOI: 10.3390/cells9051074

Glial Alterations in Aging and Alzheimer’s disease: A novel basis to understand, prevent and treat the degenerative process
Toledano-Díaz A, Álvarez MI, Toledano A.
OBM GERIATRICS 4 (2020)
DOI: 10.21926/obm.geriatr.2002117

Hippocampal CCR5/RANTES elevations in a rodent model of post-traumatic stress disorder: Maraviroc (a CCR5 Antagonist) increases corticosterone levels and enhances fear memory consolidation
Merino JJ, Muñetón-Gomez V, Muñetón-Gómez C, Pérez-Izquierdo MÁ, Loscertales M, Toledano A.
BIOMOLECULES FEB 1; 10(2):212 (2020)
DOI: 10.3390/biom10020212

Synthesis, neuroprotective and antioxidant capacity of PBN-related indanonitrones
Jimenez-Almarza, A; Diez-Iriepa, D; Chioua, M; Chamorro, B; Iriepa, I; Martinez-Murillo, R; Hadjipavlou-Litina, D; Oset-Gasque, MJ and Marco-Contelles, J
May 2019 | BIOORGANIC CHEMISTRY 86, pp.445-451, 2019
DOI: 10.1016/j.bioorg.2019.01.071

Slowdown intracranial glioma progression by optical hyperthermia therapy: study on a CT-2A mouse astrocytoma model
Casanova-Carvajal, O; Urbano-Bojorge, AL; Ramos, M; Serrano-Olmedo, JJ; and Martinez-Murillo, R
NANOTECHNOLOGY 30 (35), 2019
DOI: 10.1088/1361-6528/ab2164

Elevated systemic L-Kynurenine/L-Tryptophan ratio andi increased IL-1 beta and Chemokine (CX3CL1, MCP-1) proinflammatory mediators in patients with long-term titanium dental implants
Merino JJ, Cabaña Muñoz ME, Toledano A, Garcimartín A, Benedí, J, Camacho Alonso F, Parmigiani Izquierdo JM.
J CLIN MED SEP 2; 8(9):1368 (2019)
DOI: 10.3390/jcm8091368

The long-term algae extract and aminosulphurate supplementation modulates SOD-1 activity and decrease heavymetals levels in patients with long-term dental titanium implants and amalgam fillings restorations
Merino JJ, Parmigiani Izquierdo JM, Toledano A,Cabaña Muñoz ME
ANTIOXIDANTS 2019 APR 16, 8(4):101 (2019)
DOI: 10.3390/antiox8040101. 8-4

Cortical Reshaping and Functional Recovery Induced by Silk Fibroin Hydrogels-Encapsulated Stem Cells Implanted in Stroke Animals
Fernandez-Garcia, L; Perez-Rigueiro, J; Martinez-Murillo, R ; Panetsos, F; Ramos, M; Guinea, GV; Gonzalez-Nieto, D
FRONTIERS IN CELLULAR NEUROSCIENCE 12 (2018)
DOI: 10.3389/fncel.2018.00296

The APPswe/PS1A246E mutations in an astrocytic cell line leads to increased vulnerability to oxygen and glucose deprivation, Ca2+ dysregulation, and mitochondrial abnormalities
Martin-de-Saavedra, MD; Navarro, E; Moreno-Ortega, AJ; Cunha, MP; Hernansanz-Agustin, P ; Leon, R; Cano-Abad, MF ; Martinez-Ruiz, A; Martinez-Murillo, R; Duchen, MR; Lopez, MG
JOURNAL OF NEUROCHEMISTRY 145 (2), pp.170-182 (2018)
DOI: 10.1111/jnc.14293

Neuron-Astrocyte Signaling is preserved in the Aging Brain
Gomez-Gonzalo, M ; Martin-Fernandez, M ; Martinez-Murillo, R ; Mederos, S ; Hernandez-Vivanco, A ; Jamison, S ;Fernandez AP ; Serrano, J ; Calero, P ; Futch, HS ; Corpas, R ; Sanfeliu, C ; Perea, G ; Araque, A
GLIA: 65 (4):569-580 (2017)
DOI: 10.1002/glia.23112

The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease
Serrano, MP ; Herrero-Labrador, R ; Futch, HS ; Serrano, J ; Romero, A ; Fernandez AP ; Samadi, A ; Unzeta, M ; Marco-Contelles, J ; Martinez-Murillo, R
JOURNAL OF PSYCHIATRY & NEUROSCIENCE: 42(1):59-69 (2017)
DOI: 10.1503/jpn.150209

Defective insulin signaling, mediated by inflammation, connects Obesity to Alzheimer Disease; relevant pharmacological therapies and preventive dietary interventions
Rodriguez-Casado A, Toledano-Díaz A, Toledano A.
CURR ALZH RES.; 14(8):894-911 (2017)
DOI: 10.2174/1567205014666170316161848

In Vitro evaluation of Biocompatibility of Uncoated Thermally reduced graphene and carbon nanotube-loaded PVDF Membranes with adult neural stem cell-Derived neurons and glia
Defterali, C; Verdejo, R; Majeed, S; Boschetti-de-Fierro, A; Mendez-Gomez, HR ; Diaz-Guerra, E; Fierro, D; Buhr, K; Abetz, C; Martinez-Murillo, R ; Vuluga, D; Alexandre, M; Thomassin, JM; Detrembleur, C; Jerome, C; Abetz, V; Lopez-Manchado, MA; Vicario-Abejon, C
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 4 (2016)
DOI: 10.3389/fbioe.2016.00094

Methylene blue prevents retinal damage in an experimental model of ischemic proliferative retinopathy
Rey-Funes, M; Larrayoz, IM; Fernandez, JC; Contartese, DS; Rolon, F; Inserra, PIF; Martinez-Murillo, R; Lopez-Costa, JJ; Dorfman, VB; Martinez, A; Loidl, CF
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 310 (11), pp.R1011-R101 (2016)
DOI: 10.1152/ajpregu.00266.2015

Thermally reduced graphene is a permissive material for neurons and astrocytes and de novo neurogenesis in the adult olfactory bulb in vivo
Defterali, C; Verdejo, R; Peponi, L; Martin, ED; 4Martinez-Murillo, R ; Lopez-Manchado, MA; Vicario-Abejon, C
BIOMATERIALS 82, pp.84-93 (2016)
DOI: 10.1016/j.biomaterials.2015.12.010

Long-term dynamics of somatosensory activity in a stroke model of distal middle cerebral artery oclussion
Barrios, JA ; Pisarchyk, L; Fernandez-Garcia, L; Barrio, LC; Ramos, M; Martinez-Murillo, R; Gonzalez-Nieto, D
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 36 (3) , pp.606-620 (2016)
DOI: 10.3390/ijms22105091

Adrenomedullin Expression in Alzheimer's Brain
Fernandez AP; Masa, JS ; Guedan, MA ; Futch, HS ; Martinez-Murillo, R
CURRENT ALZHEIMER RESEARCH: 13 (4): 428-438 (2016)
DOI: 10.2174/1567205013666160229112725

ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's disease Therapy
Marco-Contelles J, Unzeta M, Bolea I, Esteban G, Ramsay RR, Romero A, Martinez-Murillo R, Carreiras MC, Ismaili L
FRONT NEUROSCI: 10:294 (2016)
DOI: 10.3389/fnins.2016.00294

Lack of adrenomedullin in mouse endothelial cells results in defective angiogenesis, enhanced vascular permeability, less metastasis, and more brain damage
Ochoa-Callejero L, Pozo-Rodrigalvarez A, Martinez-Murillo R, Martinez A
SCI REP; 6:33495 (2016)
DOI: 10.1038/srep33495

Brain local and regional neuroglial alterations in Alzheimer's disease: cell types, responses and implications
Toledano A, Álvarez MI, Toledano-Díaz A, Merino JJ, Rodríguez JJ.
CURR ALZH RES. 13(4):321-342 (2016)
DOI: 10.2174/1567205013666151116141217

Blood-based biomarkers of Alzheimer's disease: diagnostic algorithms and new technologies
Carmona P, Molina M, Toledano A.
ICURR ALZH RES.; 13(4):450-464 (2016)
DOI: 10.2174/1567205013666151116130301

Neuroglia in Alzheimer's Disease: From Cohort to Contestant in the Disease Progression and its Therapy
Toledano A, Merino JJ, Rodríguez JJ.
CURR ALZH RES.; 13(4):318-20 (2016)
http://hdl.handle.net/10261/149792

New concepts on the functionality of the nervous system: the revolution of the glial cells. ii. Glial responses keys in the pathogenesis and treatment of diseases of snc
Toledano A, Álvarez MI, Toledano-Díaz A, Rodríguez-Arellano JJ.
AN REAL ACAD FARM 82, 1:51-67 (2016)

ISSN (Online) 1697-4298 
http://hdl.handle.net/10261/150110

The sigma 1 Receptor Engages the Redox-Regulated HINT1 Protein to Bring Opioid Analgesia under NMDA Receptor Negative Control
Rodriguez-Munoz, M; Sanchez-Blazquez, P ; Herrero-Labrador, R; Martinez-Murillo, R ; Merlos, M; Vela, JM; Garzon, J
ANTIOXIDANTS & REDOX SIGNALING 22 (10) , pp.799-818 (2015)
DOI: 10.1089/ars.2014.5993

Vibrational spectroscopic analysis of peripheral blood plasma of patients with Alzheimer's disease
Carmona P, Molina M, López-Tobar E, Toledano A.
ANAL BIOANAL CHEM 407 (25):7747-56 (2015)
DOI: 10.1007/s00216-015-8940-7

Astroglial cell subtypes in the cerebella of normal adults, elderly adults, and patients with Alzheimer's disease: a histological and immunohistochemical comparison
Alvarez MI, Rivas L, Lacruz C, Toledano A.
GLIA 63(2):287-312. (2015)
DOI: 10.1002/glia.22751

Ultrastructural changes in the progress of natural Scrapie regardless fixation protocol
Casanova-Carvajal, O; Zeinoun, M; Urbano-Bojorge, AL; Bacha, F; Livi, JS; Agudo, E; Vargas, G; Sarasa R, Junquera C, Toledano A, Badiola JJ, Monzón M.
HISTOCHEM CELL BIOL144 (1):77-85 (2015)
DOI 10.1007/s00418-015-1314-6

New concepts on the functionality of the nervous system: the revolution of the glial cells. I. The neuro-glial relationships
Toledano A, Álvarez MI, Toledano-Díaz A.
AN REAL ACAD FARM VOL. 81, 1:11-18 (2015)

ISSN (Online) 1697-4298 
http://hdl.handle.net/10261/155110

About the vibrational spectroscopy in the diagnosis of Alzheimer's disease
Carmona P, López-Tobar E, Molina M, Toledano A.
AN REAL ACAD FARM. 81, 1:19 –24 (2015)
http://hdl.handle.net/10261/128196

Methamphetamine Causes Degeneration of Dopamine Cell Bodies and Terminals of the Nigrostriatal Pathway Evidenced by Silver Staining
Ares-Santos, S; Granado, N; Espadas, I; Martinez-Murillo, R; Moratalla, R
NEUROPSYCHOPHARMACOLOGY 39 (5), pp.1066-1080 (2014)
DOI: 10.1038/npp.2013.307

Donepezil plus propargylamine+8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease
Wang, L ; Esteban, G ; Ojima, M ; Bautista-Aguilera, OM ; Inokuchi, T ; Moraleda, I ; Iriepa, I ; Samadi, A ; Youdim, MBH ; Romero, A ; Soriano, E ; Herrero, R ; Fernandez, APF ; Ricardo-Martinez-Murillo ; Marco-Contelles, J ; Unzeta M
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY: 80: 543-561(2014)
DOI: 10.1016/j.ejmech.2014.04.078

Astrocytes require insulin-like growth factor I to protect neurons against oxidative injury
Genis, Laura; Davila, David; Fernandez, Silvia; Pozo-Rodrigalvarez, Andrea; Martinez-Murillo, Ricardo; Torres-Aleman, Ignacio
F1000Research 3, pp.28 (2014)
DOI: 10.12688/f1000research.3-28.v2

Morphological approach to assess the involvement of astrocytes in prion propagation
Hernández RS, Sarasa R, Toledano A, Badiola JJ, Monzón M.
CELL TISSUE RES. 2014 OCT; 358(1):57-63. (2014)
DOI: 10.1007/s00441-014-1928-3

Variability in the effects of nicotine on different regions of the brain: changes in the concentration of superoxide dismutase isoforms
Toledano A, Álvarez MI, Toledano-Díaz A.
Cent Nerv Syst Agents Med Chem.; 14(1):10-22. (2014)
DOI: 10.2174/1871524914666140507162907

Does Alzheimer's disease exist in all primates? Alzheimer pathology in non-human primates and its pathophysiological implications (II)
Toledano A, Álvarez MI, López-Rodríguez AB, Toledano-Díaz A, Fernández-Verdecia CI.
NEUROLOGIA 29(1):42-55 (2014)
DOI: 10.1016/j.nrl.2011.05.004

Hypothermia prevents gliosis and angiogenesis development in an experimental model of ischemic proliferative retinopathy
Rey-Funes M, Dorfman VB, Ibarra ME, Pena E, Contartese DS, Goldstein J, Acosta JM, Larrayoz IM, Martinez-Murillo R, Martinez A, Loidl CF
INVEST OPHTHALMOL VIS SCI 23-4-; 54:2836-2846 (2013)
DOI: 10.1167/iovs.12-11198

Could neurotransmitters influence neurogenesis and neurorepair after stroke?
Sanchez-Mendoza E, Bellver-Landete V, Merino JJ, Gonzalez MP, Martinez-Murillo R, Oset-Gasque MJ
NEUROPATHOL APPL NEUROBIOL 39:722-735 (2013)
DOI: 10.1111/nan.12082

Discrimination analysis of blood plasma associated with Alzheimer's disease using vibrational spectroscopy
Carmona P, Molina M, Calero M, Bermejo-Pareja F, Martínez-Martín P, Toledano A.
J ALZHEIMERS DIS.; 34(4):911-920 (2013)
DOI: 10.3233/JAD-122041

Brain repair after ischemic stroke: role of neurotransmitters in post-ischemic neurogenesis
Sanchez-Mendoza E, Bellver-Landete V, Gonzalez MP, Merino JJ, Martinez-Murillo R, Oset-Gasque MJ
REV NEUROL 1-11-55:533-542 (2012)
DOI: 10.33588/rn.5509.2012316

Neural differentiation of transplanted neural stem cells in a rat model of striatal lacunar infarction: light and electron microscopic observations
Muneton-Gomez, VC ; Doncel-Perez, E ; Fernandez AP ; Serrano, J ; Pozo-Rodrigalvarez, A ; Vellosillo-Huerta, L ; Taylor, JS ; Cardona-Gomez, GP ; Nieto-Sampedro, M ; Martinez-Murillo, R
FRONTIERS IN CELLULAR NEUROSCIENCE: 6:30 (2012)
DOI: 10.3389/fncel.2012.00030

New synthesis and promising neuroprotective role in experimental ischemic stroke of ONO-1714
Pozo-Rodrigalvarez, A ; Gradillas, A ; Serrano, J ; Fernandez AP ; Martinez-Murillo, R ; Perez-Castells, J
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY: 54: 439-446 (2012)
DOI: 10.1016/j.ejmech.2012.05.031

Infrared spectroscopic analysis of mononuclear leukocytes in peripheral blood from Alzheimer's disease patients
Carmona P, Molina M, Calero M, Bermejo-Pareja F, Martínez-Martín P, Alvarez MI, Toledano A.
ANAL BIOANAL CHEM. 2012 FEB; 402(6):2015-21 (2012)
DOI: 10.1007/s00216-011-5669-9

Does Alzheimer's disease exist in all primates? Alzheimer pathology in non-human primates and its pathophysiological implications (I)
Toledano A, Alvarez MI, López-Rodríguez AB, Toledano-Díaz A, Fernández-Verdecia CI.
NEUROLOGIA 27(6):354-69. (2012)
DOI: 10.1016/j.nrleng.2012.07.002

Changes induced by natural Scrapie in the calretinin-immunopositive cells and fibres of the sheep cerebellar cortex
A. Toledano, MI. Alvarez, E. Monleón, A. Toledano Diaz, JJ.Badiola, M. Monzon
CEREBELLUM 11: 593-604 (2012)
DOI: 10.1007/s12311-011-0335-5

Adrenomedullin and Nitric Oxide: Implications for the Etiology and Treatment of Primary Brain Tumors
Fernandez AP ; Serrano, J ; Amorim, MA ; Pozo-Rodrigalvarez, A ; Martinez-Murillo, R
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS: 10 (7): 820-833 (2011)
DOI: 10.2174/187152711798072374

Hypothermia Prevents Nitric Oxide System Changes in Retina Induced by Severe Perinatal Asphyxia
Rey-Funes, M ; Ibarra, ME ; Dorfman, VB ; Serrano, J ; Fernandez AP ; Martinez-Murillo, R ; Martinez, A ; Coirini, H ; Rodrigo, J ; Loidl, CF
JOURNAL OF NEUROSCIENCE RESEARCH: 89 (5): 729-743 (2011)
DOI: 10.1002/jnr.22556

SUMO-SIM interactions regulate the activity of RGSZ2 proteins
Garzon J, Rodriguez-Munoz M, Vicente-Sanchez A, Garcia-Lopez MA, Martinez-Murillo R, Fischer T, Sanchez-Blazquez P
PLoS One; 6:e28557 (2011)
DOI: 10.1371/journal.pone.0028557

RGSZ2 binds to the neural nitric oxide synthase PDZ domain to regulate mu-opioid receptor-mediated potentiation of the N-methyl-D-aspartate receptor-calmodulin-dependent protein kinase II pathway
Garzon J, Rodriguez-Munoz M, Vicente-Sanchez A, Bailon C, Martinez-Murillo R, Sanchez-Blazquez P
ANTIOXID REDOX SIGNAL 15-8-; 15:873-887 (2011)
DOI: 10.1089/ars.2010.3767

Recommendations guide for experimental animal models in stroke research
Garcia-Bonilla L, Rosell A, Torregrosa G, Salom JB, Alborch E, Gutierrez M, Tejedor E, Martinez-Murillo R, Agulla J, Ramos-Cabrer P, Castillo J, Gasull T, Montaner J
NEUROLOGIA; 26:105-110 (2011)
DOI: 10.1016/S2173-5808(11)70021-9

Lack of Adrenomedullin in the Central Nervous System Results in Apparently Paradoxical Alterations on Pain Sensitivity
Fernandez AP ; Serrano, J ; Martinez-Murillo, R ; Martinez, A
ENDOCRINOLOGY: 151(10):4908-4915(2010)
DOI: 10.1210/en.2010-0121

High sensitivity to carcinogens in the brain of a mouse model of Alzheimer's disease
Serrano, J ; Fernandez AP ; Martinez-Murillo, R ; Martinez, A
ONCOGENE: 29(15):2165-2171(2010)
DOI: 10.1038/onc.2009.503

Lack of adrenomedullin affects growth and differentiation of adult neural stem/progenitor cells
Vergano-Vera, E ; Fernandez AP ; Hurtado-Chong, A ] ; Vicario-Abejon, C ; Martinez, A
CELL AND TISSUE RESEARCH: 340(1): 1-11 (2010)
DOI: 10.3390/ijms22105091

Lack of adrenomedullin, but not complement factor H, results in larger infarct size and more extensive brain damage in a focal ischemia model
O. Hurtado, J. Serrano, M. Sobrado, A.P. Fernández, I. Lizasoaín, R. Martínez-Murillo, M.A. Moro and A. Martínez
NEUROSCIENCE: 171(3):885-892 (2010)
DOI: 10.1016/j.neuroscience.2010.09.021

Nitric Oxide: Target for Therapeutic Strategies in Alzheimer's disease
Fernandez AP ; Pozo-Rodrigalvarez, A ; Serrano, J ; Martinez-Murillo, R
CURRENT PHARMACEUTICAL DESIGN: 16(25): 2837-2850 (2010)
DOI: 10.2174/138161210793176590

Cajal's achievements in the field of the development of dendritic arbors
Garcia-Lopez, P; Garcia-Marin, V; Martinez-Murillo, R; Freire, M
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY 54 (2010)
DOI: 10.1387/ijdb.093001pg

Diversity and variability of the nicotine effects on different brain cortical regions of the brain. Therapeutic and toxicologic implications
Toledano A; M. I. Álvarez, Toledano-Díaz
CENTRAL NERVOUS SYSTEM AGENTS IN MEDICINAL CHEMISTRY 10:180-206 (2010)
DOI: 10.2174/1871524911006030180